Laura was born in Palermo and made her operatic debut at very young age in the title roles of the opera I Pazzi per progetto by Donizetti and Adina by Rossini at the Teatro Massimo in Palermo. She began her vocal studies with Maria Chiara and Alida Ferrarini and she perfected with Luciana Serra. 

From that moment on she began her journey as an artist, that has taken her to the most prestigious international stages and she collaborated with many distinguished opera conductors, such as Riccardo Muti, Zubin Metha, Antonio Pappano, Riccardo Chailly, Valery Gergiev, Myun Whun Chung, Gianandrea Noseda, Jesus Lopez Cobos, Gabriele Ferro, Rinaldo Alessandrini, Yuri Bashmet, Kazushi Ono, Christophe Rousset, Ottavio Dantone, Maurizio Benini, Fabrizio Maria Carminati, Jean-Christophe Spinosi, Nello Santi, Alberto Zedda, Paolo Arrivabeni, Michel Plasson, Daniel Harding and she was directed by stage directors such as Franco Zeffirelli, Pier Luigi Pizzi, Robert Carsen, Hugo De Ana, Roberto Andò, Filippo Crivelli, Emilio Sagi, Peter Stein, Giorgio Barberio Corsetti, Michael Hampe, Willy Decker, Giancarlo Del Monaco. 

Among her best performances are: Donizetti's I pazzi per progetto and Rossini's Adina at Teatro Massimo di Palermo; Don Pasquale (Norina) in Ravenna, Liège, Théâtre des Champs-Elysées in Paris, in Kohln; at Bolshoi in Moscow, Santiago del Cile, Treviso, Ferrara and Catania; La Bohème (Musetta) at Teatro Alla Scala in Milano, at Teatro Real de Madrid, at Teatro alla Fenice in Venice, at Opéra Royale de Wallonie in Liege, at Teatro Bellini in Catania; L’elisir d’amore (Adina) in Las Palmas, Tel Aviv, Maribor, Palermo and at Opera di Firenze; Le nozze di Figaro (Susanna) at Semper Oper in Dresden, at Teatro Carlo Felice in Genova, at Opéra Bastille in Paris, in Reggio Emilia and at Teatro Regio in Parma; Falstaff (Nannetta) at Teatro alla Scala di Milano, in Strasburg, Roma, Lyon, Santa Fe, Torino, at Sveriges Radio Symphony Orchestra inStockholm , at Bayerische Rundfunk in Münich; La fille du régiment (Marie) in in Savonlinna with Teatro Comunale di Bologna, in Lecce and Palermo; Cimarosa's Il ritorno di Don Calandrino (Livietta) at Salzburger Festspiele Pfingsten, Piacenza, Pisa and Ravenna; Così fan tutte (Despina) at Teatro Massimo di Palermo and at Opernhaus in Zürich; Gianni Schicchi (Lauretta) in Lisbona; Rigoletto (Gilda) in Seoul, Ancona and Fano; Il cappello di paglia di Firenze (Elena) at Maggio Musicale Fiorentino; Don Giovanni (Zerlina) at Opernhaus in Zürich ;Carmina Burana at Teatro dell'Opera di Roma and at Arenes de Nimes ; Poulenc's Stabat Mater at Massimo di Palermo; La vedova allegra (Valencienne) at Teatro Regio di Torino; Il viaggio a Reims (Corinna) at Festival Rossini in Wildbad, at Teatro Real de Madrid, at Festival Rossini di Pesaro; Don Giovanni (Donna Anna) in Palermo, Fano and Trieste, Le Toreador (Coraline) e Die Zauberflöte (Pamina) in Palermo; Donizetti's Betly in Berlin ; I Puritani (Elvira) at Teatro Bellini di Catania and at Teatro Massimo in Palermo; Les pecheurs de perles (Leila) at Opera di Firenze; Olivo e Pasquale at Festival Donizetti di Bergamo ; Un Ballo in Maschera (Oscar) in Nizza, Trieste e and at Accademia di Santa Cecilia in Roma; Gounod's La Colombe (Sylvie) at Accademia Chigiana di Siena; Spontini's La Fuga in Maschera at Teatro San Carlo di Napoli; Rossini's La Pietra del Paragone at Theatre Chatelet in Paris; Cimarosa's Il Matrimonio Segreto at Theatre du Champs Elisées in Paris and at Teatro Massimo di Palermo; Vivaldi's L'Olimpiade (Aminta) at Beaune Festival International d'Opéra Baroque ; Carmen (Micaela) at Teatro la Fenice in Venice and Teatro del Maggio Musicale Fiorentino in Florence; La Sonnambula (Amina) at Teatro del Maggio Fiorentino in Florence; La Traviata (Violetta) at Teatro Cilea in Reggio Calabria; Oscar in Un Ballo in Maschera for the opening night of the season at the Regio in Parma. She has been performing in concerts intensively and internationally, in both classical and contemporary repertoires, including oratorios, sacred music, melodies by Mozart, Rossini, Vivaldi, Bach, Bellini, Poulenc, Fauré, Berlioz e Mahler. 

Laura realized also un exciting collaboration with Rai 1 (Italian television), participating in some of the most successful live broadcasts of the season, Il meglio d'Italia hosted by a famous showman Enrico Brignano, which permitted her to become known to an even broader audience. Laura was called to represent Italian opera and performed excerpts from Rigoletto and La traviata.In the same year she participated in her first movie as an actress, Il Figlio Sospeso, produced and directed by Egidio Termine. Laura Giordano recorded Vivaldi’s L’Olimpiade with Rinaldo Alessandrini (Opus 11) and a previously unpublished duet by Rossini with Riccardo Chailly (Decca). She sings Musetta in La bohème on the DVD recording of the performance at Teatro Real de Madrid, Norina in Don Pasquale conducted by Riccardo Muti, Fulvia in La pietra del paragone conducted by Jean-Christophe Spinosi, Corinna in Il viaggio a Reims recorded by Naxos and Isabella in Donizetti's Olivo e Pasquale by Dynamic, Pêchées de Vieillesse (Naxos).